Infection and injury of human astrocytes by tick-borne encephalitis virus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00435256" target="_blank" >RIV/60077344:_____/14:00435256 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/14:43887264 RIV/00027162:_____/14:#0001180 RIV/00027162:_____/14:#0001333
Result on the web
<a href="http://dx.doi.org/10.1099/vir.0.068411-0" target="_blank" >http://dx.doi.org/10.1099/vir.0.068411-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1099/vir.0.068411-0" target="_blank" >10.1099/vir.0.068411-0</a>

Result language
angličtina
Original language name
Infection and injury of human astrocytes by tick-borne encephalitis virus
Original language description
Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents the most important flaviviral neural infection in Europe and north-eastern Asia. In the central nervous system (CNS), neurons are the primary target for TBEV infection; however, infection of non-neuronal CNS cells, such as astrocytes, is not well understood. In this study, we investigated the interaction between TBEV and primary human astrocytes. We report for the first time, to the best of our knowledge,that primary human astrocytes are sensitive to TBEV infection, although the infection did not affect their viability. The infection induced a marked increase in the expression of glial fibrillary acidic protein, a marker of astrocyte activation. In addition, expression of matrix metalloproteinase 9 and several key pro-inflammatory cytokines/chemokines (e.g. tumour necrosis factor alpha, interferon alpha, interleukin (IL)-1beta, IL-6, IL-8, interferon gamma-induced protein 10, macrophage
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)