Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00446264" target="_blank" >RIV/60077344:_____/15:00446264 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/15:00446264 RIV/00216224:14740/15:00080881

Result on the web

<a href="http://dx.doi.org/10.1093/nar/gkv296" target="_blank" >http://dx.doi.org/10.1093/nar/gkv296</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gkv296" target="_blank" >10.1093/nar/gkv296</a>

Result language

angličtina

Original language name

Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA

Original language description

There are two basic mechanisms that are associated with the maintenance of the telomere length, which endows cancer cells with unlimited proliferative potential. One mechanism, referred to as alternative lengthening of telomeres (ALT), accounts for approximately 10-15% of all human cancers. Tumours engaged in the ALT pathway are characterised by the presence of the single stranded 5'-C-rich telomeric overhang (C-overhang). This recently identified hallmark of ALT cancers distinguishes them from healthytissues and renders the C-overhang as a clear target for anticancer therapy. We analysed structures of the 5'-C-rich and 3'-G-rich telomeric overhangs from human and Caenorhabditis elegans, the recently established multicellular in vivo model of ALT tumours. We show that the telomeric DNA from C. elegans and humans forms fundamentally different secondary structures. The unique structural characteristics of C. elegans telomeric DNA that are distinct not only from those of humans but also

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

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Volume of the periodical

43

Issue of the periodical within the volume

9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

4733-4745

UT code for WoS article

000355928800035

EID of the result in the Scopus database

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