Heme pathway evolution in kinetoplastid protists
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00461848" target="_blank" >RIV/60077344:_____/16:00461848 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/16:43890618
Result on the web
<a href="http://dx.doi.org/10.1186/s12862-016-0664-6" target="_blank" >http://dx.doi.org/10.1186/s12862-016-0664-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12862-016-0664-6" target="_blank" >10.1186/s12862-016-0664-6</a>
Alternative languages
Result language
angličtina
Original language name
Heme pathway evolution in kinetoplastid protists
Original language description
Background: Kinetoplastea is a diverse protist lineage composed of several of the most successful parasites on Earth, organisms whose metabolisms have coevolved with those of the organisms they infect. Parasitic kinetoplastids have emerged from free-living, non-pathogenic ancestors on multiple occasions during the evolutionary history of the group. Interestingly, in both parasitic and free-living kinetoplastids, the heme pathway-a core metabolic pathway in a wide range of organisms-is incomplete or entirely absent. Indeed, Kinetoplastea investigated thus far seem to bypass the need for heme biosynthesis by acquiring heme or intermediate metabolites directly from their environment. nnResults: Here we report the existence of a near-complete heme biosynthetic pathway in Perkinsela spp., kinetoplastids that live as obligate endosymbionts inside amoebozoans belonging to the genus Paramoeba/Neoparamoeba. We also use phylogenetic analysis to infer the evolution of the heme pathway in Kinetoplastea. nnConclusion: We show that Perkinsela spp. is a deep-branching kinetoplastid lineage, and that lateral gene transfer has played a role in the evolution of heme biosynthesis in Perkinsela spp. and other Kinetoplastea. We also discuss the significance of the presence of seven of eight heme pathway genes in the Perkinsela genome as it relates to its endosymbiotic relationship with Paramoeba.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Evolutionary Biology
ISSN
1471-2148
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
MAY 18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
18
Pages from-to
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UT code for WoS article
000375988600004
EID of the result in the Scopus database
2-s2.0-84975065656