The Mastigamoeba balamuthi Genome and the Nature of the Free-Living Ancestor of Entamoeba
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F21%3AA2202AFL" target="_blank" >RIV/61988987:17310/21:A2202AFL - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00555440 RIV/68378050:_____/21:00555440 RIV/00216208:11310/21:10430985
Result on the web
<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:000664191500005" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:000664191500005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/molbev/msab020" target="_blank" >10.1093/molbev/msab020</a>
Alternative languages
Result language
angličtina
Original language name
The Mastigamoeba balamuthi Genome and the Nature of the Free-Living Ancestor of Entamoeba
Original language description
The transition of free-living organisms to parasitic organisms is a mysterious process that occurs in all major eukaryotic lineages. Parasites display seemingly unique features associated with their pathogenicity; however, it is important to distinguish ancestral preconditions to parasitism from truly new parasite-specific functions. Here, we sequenced the genome and transcriptome of anaerobic free-living Mastigamoeba balamuthi and performed phylogenomic analysis of four related members of the Archamoebae, including Entamoeba histolytica, an important intestinal pathogen of humans. We aimed to trace gene histories throughout the adaptation of the aerobic ancestor of Archamoebae to anaerobiosis and throughout the transition from a free-living to a parasitic lifestyle. These events were associated with massive gene losses that, in parasitic lineages, resulted in a reduction in structural features, complete losses of some metabolic pathways, and a reduction in metabolic complexity. By reconstructing the features of the common ancestor of Archamoebae, we estimated preconditions for the evolution of parasitism in this lineage. The ancestor could apparently form chitinous cysts, possessed proteolytic enzyme machinery, compartmentalized the sulfate activation pathway in mitochondrion-related organelles, and possessed the components for anaerobic energy metabolism.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOL BIOL EVOL
ISSN
0737-4038
e-ISSN
1537-1719
Volume of the periodical
38
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
2240-2259
UT code for WoS article
000664191500005
EID of the result in the Scopus database
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