The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00465215" target="_blank" >RIV/60077344:_____/16:00465215 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/16:43891909

Result on the web

<a href="http://dx.doi.org/10.1042/BCJ20160563" target="_blank" >http://dx.doi.org/10.1042/BCJ20160563</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1042/BCJ20160563" target="_blank" >10.1042/BCJ20160563</a>

Result language

angličtina

Original language name

The silent information regulator 1 (Sirt1) is a positive regulator of the Notch pathway in Drosophila

Original language description

The silent information regulator 1 (Sirt1) has previously been shown to have negative effects on the Notch pathway in several contexts. We bring evidence that Sirt1 has a positive effect on Notch activation in Drosophila, in the context of sensory organ precursor specification and during wing development. The phenotype of Sirt1 mutant resembles weak Notch loss of function phenotypes and genetic interactions of Sirt1 with the components of the Notch pathway also suggest a positive role of Sirt1 in Notch signalling. Sirt1 is necessary for the efficient activation of E(spl) genes by Notch in S2N cells. Additionally, the Notch dependent response of several E(spl) genes is sensitive to metabolic stress caused by 2-deoxyglucose treatment, in a Sirt1 dependent manner. We found Sirt1 associated with several proteins involved in Notch repression as well as activation, including the cofactor exchange factor ebi (TBL1), the RLAF/LAF histone chaperon complex and the Tip60 acetylation complex. Moreover, Sirt1 participates in the deacetylation of the CSL transcription factor Su(H). The role of Sirt1 in Notch signalling is therefore more complex than previously recognised and its diverse effects may be explained by a plethora of Sirt1 substrates involved in the regulation of Notch signalling.n

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/GA14-08583S" target="_blank" >GA14-08583S: The role of sirtuins in Notch signalling and Drosophila development</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Journal

ISSN

0264-6021

e-ISSN

—

Volume of the periodical

473

Issue of the periodical within the volume

22

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

4129-4143

UT code for WoS article

000393759300004

EID of the result in the Scopus database

2-s2.0-85009516150