Dissecting the mechanisms of Notch induced hyperplasia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00394114" target="_blank" >RIV/60077344:_____/13:00394114 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/13:43886299

Result on the web

<a href="http://www.nature.com/emboj/journal/v32/n1/pdf/emboj2012326a.pdf" target="_blank" >http://www.nature.com/emboj/journal/v32/n1/pdf/emboj2012326a.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/emboj.2012.326" target="_blank" >10.1038/emboj.2012.326</a>

Result language

angličtina

Original language name

Dissecting the mechanisms of Notch induced hyperplasia

Original language description

The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to identify the Notch-CSL target genes directly activated during wing disc hyperplasia. Amongthem were genes involved in both autonomous and non-autonomous regulation of proliferation, growth and cell death, providing molecular explanations for many characteristics of Notch induced wing disc hyperplasia previously reported. The Notch targets exhibit different response patterns, which are shaped by both positive and negative feed-forward regulation between the Notch targets themselves. We propose, therefore, that both the characteristics of the direct Notch targets and their cros

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

EMBO Journal

ISSN

0261-4189

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

60-71

UT code for WoS article

000314141900007

EID of the result in the Scopus database

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