Notch co-operates with Lozenge/Runx to lock hemocytes into a differentiation programme
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00394130" target="_blank" >RIV/60077344:_____/13:00394130 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1242/dev.086785" target="_blank" >http://dx.doi.org/10.1242/dev.086785</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/dev.086785" target="_blank" >10.1242/dev.086785</a>
Alternative languages
Result language
angličtina
Original language name
Notch co-operates with Lozenge/Runx to lock hemocytes into a differentiation programme
Original language description
The diverse functions of Notch signalling imply that it must elicit context-specific programmes of gene expression. With the aim of investigating how Notch drives cells to differentiate, we have used a genome-wide approach to identify direct Notch targets in Drosophila haemocytes (blood cells), where Notch promotes crystal cell differentiation. Many of the identified Notch-regulated enhancers contain Runx and GATA motifs, and we demonstrate that binding of the Runx protein Lozenge (Lz) is required for enhancers to be competent to respond to Notch. Functional studies of targets, such as klumpfuss (ERG/WT1 family) and pebbled/hindsight (RREB1 homologue), show that Notch acts both to prevent the cells adopting alternate cell fates and to promote morphological characteristics associated with crystal cell differentiation. Inappropriate activity of Klumpfuss perturbs the differentiation programme, resulting in melanotic tumours. Thus, by acting as a master regulator, Lz directs Notch to acti
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP305%2F11%2F0126" target="_blank" >GAP305/11/0126: Notch signalling at the context of cellular metabolism.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Development
ISSN
0950-1991
e-ISSN
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Volume of the periodical
140
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
926-937
UT code for WoS article
000314405000023
EID of the result in the Scopus database
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