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Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F13%3A43886298" target="_blank" >RIV/60076658:12310/13:43886298 - isvavai.cz</a>

  • Result on the web

    <a href="http://dev.biologists.org/content/140/4/926.full.pdf+html" target="_blank" >http://dev.biologists.org/content/140/4/926.full.pdf+html</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1242/dev.086785" target="_blank" >10.1242/dev.086785</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme

  • Original language description

    The diverse functions of Notch signalling imply that it must elicit context-specific programmes of gene expression. With the aim of investigating how Notch drives cells to differentiate, we have used a genome-wide approach to identify direct Notch targets in Drosophila haemocytes (blood cells), where Notch promotes crystal cell differentiation. Many of the identified Notch-regulated enhancers contain Runx and GATA motifs, and we demonstrate that binding of the Runx protein Lozenge (Lz) is required for enhancers to be competent to respond to Notch. Functional studies of targets, such as klumpfuss (ERG/WT1 family) and pebbled/hindsight (RREB1 homologue), show that Notch acts both to prevent the cells adopting alternate cell fates and to promote morphological characteristics associated with crystal cell differentiation. Inappropriate activity of Klumpfuss perturbs the differentiation programme, resulting in melanotic tumours. Thus, by acting as a master regulator, Lz directs Notch to acti

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Development

  • ISSN

    0950-1991

  • e-ISSN

  • Volume of the periodical

    140

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    926-937

  • UT code for WoS article

    000314405000023

  • EID of the result in the Scopus database