Metagenomic recovery of phage genomes of uncultured freshwater actinobacteria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00479538" target="_blank" >RIV/60077344:_____/17:00479538 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/ismej.2016.110" target="_blank" >http://dx.doi.org/10.1038/ismej.2016.110</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ismej.2016.110" target="_blank" >10.1038/ismej.2016.110</a>
Alternative languages
Result language
angličtina
Original language name
Metagenomic recovery of phage genomes of uncultured freshwater actinobacteria
Original language description
Low-GC Actinobacteria are among the most abundant and widespread microbes in freshwaters and have largely resisted all cultivation efforts. Consequently, their phages have remained totally unknown. In this work, we have used deep metagenomic sequencing to assemble eight complete genomes of the first tailed phages that infect freshwater Actinobacteria. Their genomes encode the actinobacterial-specific transcription factor whiB, frequently found in mycobacteriophages and also in phages infecting marine pelagic Actinobacteria. Its presence suggests a common and widespread strategy of modulation of host transcriptional machinery upon infection via this transcriptional switch. We present evidence that some whiB-carrying phages infect the acI lineage of Actinobacteria. At least one of them encodes the ADP-ribosylating component of the widespread bacterial AB toxins family (for example, clostridial toxin). We posit that the presence of this toxin reflects a 'trojan horse' strategy, providing protection at the population level to the abundant host microbes against eukaryotic predators.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/GA13-00243S" target="_blank" >GA13-00243S: Unveiling life strategies of selected groups of planktonic Betaproteobacteria in relationship to carbon flow to higher trophic levels</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The ISME Journal
ISSN
1751-7362
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
304-308
UT code for WoS article
000394537700028
EID of the result in the Scopus database
2-s2.0-84981273805