Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F18%3A00488923" target="_blank" >RIV/60077344:_____/18:00488923 - isvavai.cz</a>
Result on the web
<a href="http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007241" target="_blank" >http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007241</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pgen.1007241" target="_blank" >10.1371/journal.pgen.1007241</a>
Alternative languages
Result language
angličtina
Original language name
Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture
Original language description
Apico-basal polarity is critical for integrity and function of epithelial tissues and its loss is one of the hallmarks of cancer. This study shows that in the fruit fly Drosophila melanogaster breakdown of epithelial polarity engages Activating transcription factor 3 (Atf3), a protein that directly binds the DNA and regulates gene expression. As such, the abnormally induced activity of Atf3 drives many defects in the epithelial function and differentiation, whereas removal of Atf3 in this context is beneficial. Given the evolutionary conservation of Atf3 between flies and humans, these findings may contribute to a better understanding of diseases stemming from compromised epithelial polarity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LM2015062" target="_blank" >LM2015062: National Infrastructure for Biological and Medical Imaging</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Genetics
ISSN
1553-7404
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
32
Pages from-to
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UT code for WoS article
000428840600012
EID of the result in the Scopus database
2-s2.0-85044834336