Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00338123" target="_blank" >RIV/60077344:_____/10:00338123 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Original language description

Animal development involves movements and fusions of epithelia. During metamorphosis of Drosophila, the precursor cells of abdominal epidermis (histoblasts) divide and migrate while replacing larval epidermal cells (LECs), which must depart from the epithelium to allow histoblast fusion and formation of the adult epidermis. Regulation of this morphogenetic cell replacement is unclear. We have found that temporally misregulated activity of the transcription factor Atf3 prevents LEC extrusion by interfering with the Rho signaling, leading to increased adhesiveness of LECs that consequently obstruct the closure of the adult abdominal epithelium. To elicit this effect, Atf3 requires its binding partner Jun. Although dimerization between the two important regulatory bZIP proteins has been well-established in mammalian cell lines, our data for the first time demonstrate a developmental function for the Jun-Atf3 complex in vivo.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

<a href="/en/project/2B06129" target="_blank" >2B06129: Model organisms as a key to the understanding of functions of disease-related human genes</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Development

ISSN

0950-1991

e-ISSN

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Volume of the periodical

137

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000272977200018

EID of the result in the Scopus database

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