Mannitol treatment is not effective in therapy of rabies virus infection in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519413" target="_blank" >RIV/60077344:_____/19:00519413 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/19:N0000082
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0264410X17317814?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264410X17317814?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vaccine.2017.12.028" target="_blank" >10.1016/j.vaccine.2017.12.028</a>
Alternative languages
Result language
angličtina
Original language name
Mannitol treatment is not effective in therapy of rabies virus infection in mice
Original language description
Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice. (C) 2017 Elsevier Ltd. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Vaccine
ISSN
0264-410X
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
33
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
4710-4714
UT code for WoS article
000480669000009
EID of the result in the Scopus database
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