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Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519661" target="_blank" >RIV/60077344:_____/19:00519661 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081766:_____/19:00507240 RIV/62157124:16170/19:43877301

  • Result on the web

    <a href="https://msphere.asm.org/content/4/4/e00271-19" target="_blank" >https://msphere.asm.org/content/4/4/e00271-19</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1128/mSphere.00271-19" target="_blank" >10.1128/mSphere.00271-19</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints

  • Original language description

    The gut microbiome of primates, including humans, is reported to closely follow host evolutionary history, with gut microbiome composition being specific to the genetic background of its primate host. However, the comparative models used to date have mainly included a limited set of closely related primates. To further understand the forces that shape the primate gut microbiome, with reference to human populations, we expanded the comparative analysis of variation among gut microbiome compositions and their primate hosts, including 9 different primate species and 4 human groups characterized by a diverse set of subsistence patterns (n = 448 samples). The results show that the taxonomic composition of the human gut microbiome, at the genus level, exhibits increased compositional plasticity. Specifically, we show unexpected similarities between African Old World monkeys that rely on eclectic foraging and human populations engaging in nonindustrial subsistence patterns, these similarities transcend host phylogenetic constraints. Thus, instead of following evolutionary trends that would make their microbiomes more similar to that of conspecifics or more phylogenetically similar apes, gut microbiome composition in humans from nonindustrial populations resembles that of generalist cercopithecine monkeys. We also document that wild cercopithecine monkeys with eclectic diets and humans following nonindustrial subsistence patterns harbor high gut microbiome diversity that is not only higher than that seen in humans engaging in industrialized lifestyles but also higher compared to wild primates that typically consume fiber-rich diets.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30302 - Epidemiology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    mSphere

  • ISSN

    2379-5042

  • e-ISSN

  • Volume of the periodical

    4

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    e00271-19

  • UT code for WoS article

    000483320200020

  • EID of the result in the Scopus database

    2-s2.0-85070921236