Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519822" target="_blank" >RIV/60077344:_____/19:00519822 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/19:43899850

Result on the web

<a href="https://elifesciences.org/articles/50414" target="_blank" >https://elifesciences.org/articles/50414</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.50414" target="_blank" >10.7554/eLife.50414</a>

Result language

angličtina

Original language name

Drosophila macrophages switch to aerobic glycolysis to mount effective antibacterial defense

Original language description

All rights reserved. Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycolysis. Although, the function of bactericidal macrophages is highly conserved, the metabolic remodeling of insect macrophages remains poorly understood. Here we used the adult fruit fly Drosophila melanogaster to investigate the metabolic changes that occur in macrophages during the acute and resolution phases of Streptococcus-induced sepsis. Our studies revealed that orthologs of the Hypoxia inducible factor 1α (HIF1α) and Lactate dehydrogenase (LDH) are required for macrophage activation, their bactericidal function, and resistance to infection, thus documenting conservation of this cellular response between insect and mammals. Further, we show that macrophages employing aerobic glycolysis induce changes in systemic metabolism that are necessary to meet the biosynthetic and energetic demands of their function and resistance to bacterial infection.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

OCT 14 2019

Country of publishing house

GB - UNITED KINGDOM

Number of pages

22

Pages from-to

e50414

UT code for WoS article

000498688600001

EID of the result in the Scopus database

2-s2.0-85075615080