Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00580499" target="_blank" >RIV/60077344:_____/23:00580499 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/23:43907144
Result on the web
<a href="https://www.embopress.org/doi/epdf/10.15252/embj.2023114086" target="_blank" >https://www.embopress.org/doi/epdf/10.15252/embj.2023114086</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15252/embj.2023114086" target="_blank" >10.15252/embj.2023114086</a>
Alternative languages
Result language
angličtina
Original language name
Macrophage-derived insulin antagonist ImpL2 induces lipoprotein mobilization upon bacterial infection
Original language description
The immune response is an energy-demanding process that must be coordinated with systemic metabolic changes redirecting nutrients from stores to the immune system. Although this interplay is fundamental for the function of the immune system, the underlying mechanisms remain elusive. Our data show that the pro-inflammatory polarization of Drosophila macrophages is coupled to the production of the insulin antagonist ImpL2 through the activity of the transcription factor HIF1 alpha. ImpL2 production, reflecting nutritional demands of activated macrophages, subsequently impairs insulin signaling in the fat body, thereby triggering FOXO-driven mobilization of lipoproteins. This metabolic adaptation is fundamental for the function of the immune system and an individual's resistance to infection. We demonstrated that analogically to Drosophila, mammalian immune-activated macrophages produce ImpL2 homolog IGFBP7 in a HIF1 alpha-dependent manner and that enhanced IGFBP7 production by these cells induces mobilization of lipoproteins from hepatocytes. Hence, the production of ImpL2/IGFBP7 by macrophages represents an evolutionarily conserved mechanism by which macrophages alleviate insulin signaling in the central metabolic organ to secure nutrients necessary for their function upon bacterial infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EMBO Journal
ISSN
0261-4189
e-ISSN
1460-2075
Volume of the periodical
42
Issue of the periodical within the volume
OCT
Country of publishing house
US - UNITED STATES
Number of pages
26
Pages from-to
e114086
UT code for WoS article
001082872700001
EID of the result in the Scopus database
2-s2.0-85173942783