JAK/STAT mediated insulin resistance in muscles is essential for effective immune response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F24%3A43908023" target="_blank" >RIV/60076658:12310/24:43908023 - isvavai.cz</a>

Result on the web

<a href="https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01575-0" target="_blank" >https://biosignaling.biomedcentral.com/articles/10.1186/s12964-024-01575-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12964-024-01575-0" target="_blank" >10.1186/s12964-024-01575-0</a>

Result language

angličtina

Original language name

JAK/STAT mediated insulin resistance in muscles is essential for effective immune response

Original language description

Background The metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune system at the expense of peripheral tissues. We study the mechanisms by which this metabolic reprograming occurs using the parasitoid infection of Drosophila larvae. To overcome such an immune challenge hemocytes differentiate into lamellocytes, which encapsulate and melanize the parasitoid egg. Hemocytes acquire the energy for this process by expressing JAK/STAT ligands upd2 and upd3, which activates JAK/STAT signaling in muscles and redirects carbohydrates away from muscles in favor of immune cells.Methods Immune response of Drosophila larvae was induced by parasitoid wasp infestation. Carbohydrate levels, larval locomotion and gene expression of key proteins were compared between control and infected animals. Efficacy of lamellocyte production and resistance to wasp infection was observed for RNAi and mutant animals.Results Absence of upd/JAK/STAT signaling leads to an impaired immune response and increased mortality. We demonstrate how JAK/STAT signaling in muscles leads to suppression of insulin signaling through activation of ImpL2, the inhibitor of Drosophila insulin like peptides.Conclusions Our findings reveal cross-talk between immune cells and muscles mediates a metabolic shift, redirecting carbohydrates towards immune cells. We emphasize the crucial function of muscles during immune response and show the benefits of insulin resistance as an adaptive mechanism that is necessary for survival.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/GA20-09103S" target="_blank" >GA20-09103S: Molecular mechanisms of privileged access of activated immune cells to energy in Drosophila</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Communication and Signaling

ISSN

1478-811X

e-ISSN

1478-811X

Volume of the periodical

22

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

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UT code for WoS article

001197006400008

EID of the result in the Scopus database

2-s2.0-85189210035