Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00520437" target="_blank" >RIV/60077344:_____/19:00520437 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/19:43899193
Result on the web
<a href="https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-019-3468-x" target="_blank" >https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-019-3468-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s13071-019-3468-x" target="_blank" >10.1186/s13071-019-3468-x</a>
Alternative languages
Result language
angličtina
Original language name
Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission
Original language description
Hematophagous arthropods are responsible for the transmission of a variety of pathogens that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors for some of the most frequently occurring human tick-borne diseases, particularly Lyme borreliosis and tick-borne encephalitis virus (TBEV). The search for vaccines against these diseases is ongoing. Efforts during the last few decades have primarily focused on understanding the biology of the transmitted viruses, bacteria and protozoans, with the goal of identifying targets for intervention. Successful vaccines have been developed against TBEV and Lyme borreliosis, although the latter is no longer available for humans. More recently, the focus of intervention has shifted back to where it was initially being studied which is the vector. State of the art technologies are being used for the identification of potential vaccine candidates for anti-tick vaccines that could be used either in humans or animals. The study of the interrelationship between ticks and the pathogens they transmit, including mechanisms of acquisition, persistence and transmission have come to the fore, as this knowledge may lead to the identification of critical elements of the pathogens' life-cycle that could be targeted by vaccines. Here, we review the status of our current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasites & Vectors
ISSN
1756-3305
e-ISSN
—
Volume of the periodical
12
Issue of the periodical within the volume
MAY 14 2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
229
UT code for WoS article
000468089200002
EID of the result in the Scopus database
2-s2.0-85065744129