Complex evolution of insect insulin receptors and homologous decoy receptors, and functional significance of their multiplicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00523500" target="_blank" >RIV/60077344:_____/20:00523500 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/20:00539924 RIV/61388963:_____/20:00523500 RIV/60076658:12310/20:43901227

Result on the web

<a href="https://academic.oup.com/mbe/article-pdf/doi/10.1093/molbev/msaa048/32984781/msaa048.pdf" target="_blank" >https://academic.oup.com/mbe/article-pdf/doi/10.1093/molbev/msaa048/32984781/msaa048.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/molbev/msaa048" target="_blank" >10.1093/molbev/msaa048</a>

Result language

angličtina

Original language name

Complex evolution of insect insulin receptors and homologous decoy receptors, and functional significance of their multiplicity

Original language description

Evidence accumulates that the functional plasticity of insulin and insulin-like growth factor signaling (IIS) in insects could spring, among others, from the multiplicity of insulin receptors (InRs). Their multiple variants may be implemented in the control of insect polyphenism, such as wing or caste polyphenism. Here, we present a comprehensive phylogenetic analysis of insect InR sequences in 118 species from 23 orders and investigate the role of three InRs identified in the linden bug, Pyrrhocoris apterus, in wing polymorphism control. We identified two gene clusters (Cluster I and II) resulting from an ancestral duplication in a late ancestor of winged insects, which remained conserved in most lineages, only in some of them being subject to further duplications or losses. One remarkable yet neglected feature of InR evolution is the loss of the tyrosine kinase catalytic domain, giving rise to decoys of insulin receptor in both clusters. Within the Cluster I, we confirmed the presence of the secreted decoy of insulin receptor (SDR) in all studied Muscomorpha. More importantly, we described a new tyrosine kinase-less gene (DR2) in the Cluster II, conserved in apical Holometabola for 300 million years. We differentially silenced the three P. apterus InRs and confirmed their participation in wing polymorphism control. We observed a pattern of Cluster I and II InRs impact on wing development, which differed from that postulated in planthoppers, suggesting an independent establishment of IIS control over wing development, leading to idiosyncrasies in the cooption of multiple InRs in polyphenism control in different taxa.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

—

Volume of the periodical

37

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

1775-1789

UT code for WoS article

000569060900018

EID of the result in the Scopus database

2-s2.0-85084206628