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A decade with juvenile hormone receptor

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00542422" target="_blank" >RIV/60077344:_____/21:00542422 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/abs/pii/S0065280621000011?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0065280621000011?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/bs.aiip.2021.03.001" target="_blank" >10.1016/bs.aiip.2021.03.001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A decade with juvenile hormone receptor

  • Original language description

    Juvenile hormone (JH) and ecdysteroids represent equally important nonpeptide signals governing insect reproduction and development. For a considerable time, understanding of JH action lagged behind ecdysteroid research. Arriving with a 20-year delay, the intracellular receptor for JH was finally identified as a ligand-activated bHLH-PAS transcription factor, originally named Methoprene-tolerant (Met), by virtue of the resistance Drosophila mutants exhibited to morphogenetic and lethal actions of JH and its mimic methoprene. Systemic RNAi in suitable insect models revealed the anticipated function of Met in preventing metamorphosis and promoting reproduction, thus providing the missing link to the chief roles of JH in insects. That, along with defining the JH-binding pocket and the JH-response DNA elements of Met, established the JH receptor (JHR) 10 years ago. After reviewing the functional attributes of the JHR, this chapter will focus on advances in the genetics, cell biology, and biochemistry of the JHR achieved during this past decade. Although hormone receptor function of bHLH-PAS transcription factors is unprecedented, the well-studied mammalian aryl hydrocarbon receptor (AhR) belonging to the same protein family affords functional parallels with the JHR. We can now begin to understand the mechanisms of JHR interaction with the chaperone Hsp90/83, nucleocytoplasmic transport and post-translational regulation by phosphorylation, dimerization with bHLH-PAS partner proteins, and activation by agonist ligands binding to the PAS-B domain. A section is dedicated to current efforts exploiting the JHR as a basis of chemical high-throughput screening, aimed at discovery of novel compounds for environmentally friendly control of insect pests and disease vectors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10605 - Developmental biology

Result continuities

  • Project

    <a href="/en/project/GX20-05151X" target="_blank" >GX20-05151X: Uncovering of missing genetic components and new chemical regulators of juvenile hormone signaling</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advances in Insect Physiology

  • ISSN

    0065-2806

  • e-ISSN

    2213-6800

  • Volume of the periodical

    60

  • Issue of the periodical within the volume

    JULY 7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    49

  • Pages from-to

    37-85

  • UT code for WoS article

    000748736100003

  • EID of the result in the Scopus database