Agonist-dependent action of the juvenile hormone receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00587906" target="_blank" >RIV/60077344:_____/24:00587906 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/24:43908829
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2214574524000762/pdfft?md5=e947b21312d9e8992bac1a9dbad34e0d&pid=1-s2.0-S2214574524000762-main.pdf" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2214574524000762/pdfft?md5=e947b21312d9e8992bac1a9dbad34e0d&pid=1-s2.0-S2214574524000762-main.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cois.2024.101234" target="_blank" >10.1016/j.cois.2024.101234</a>

Result language
angličtina
Original language name
Agonist-dependent action of the juvenile hormone receptor
Original language description
Juvenile hormone (JH) signaling is effected at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal to understand how these localized changes stimulate assembly of the active JHR complex, and thus fully grasp the mechanism of JHR signaling.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10605 - Developmental biology

Project
<a href="/en/project/GX20-05151X" target="_blank" >GX20-05151X: Uncovering of missing genetic components and new chemical regulators of juvenile hormone signaling</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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