Loss of timeless underlies an evolutionary transition within the circadian clock

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00552073" target="_blank" >RIV/60077344:_____/22:00552073 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/22:43905345

Result on the web

<a href="https://academic.oup.com/mbe/article-pdf/39/1/msab346/42270562/msab346.pdf" target="_blank" >https://academic.oup.com/mbe/article-pdf/39/1/msab346/42270562/msab346.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/molbev/msab346" target="_blank" >10.1093/molbev/msab346</a>

Result language

angličtina

Original language name

Loss of timeless underlies an evolutionary transition within the circadian clock

Original language description

Most organisms possess time-keeping devices called circadian clocks. At the molecular level, circadian clocks consist of transcription–translation feedback loops (TTFLs). Although some components of the negative TTFL are conserved across the animals, important differences exist between typical models, such as mouse and the fruit fly. In Drosophila, the key components are PERIOD (PER) and TIMELESS (TIM-d) proteins, whereas the mammalian clock relies on PER and CRYPTOCHROME (CRY-m). Importantly, how the clock has maintained functionality during evolutionary transitions between different states remains elusive. Therefore, we systematically described the circadian clock gene setup in major bilaterian lineages and identified marked lineage-specific differences in their clock constitution. Then we performed a thorough functional analysis of the linden bug Pyrrhocoris apterus, an insect species comprising features characteristic of both the Drosophila and the mammalian clocks. Unexpectedly, the knockout of timeless-d, a gene essential for the clock ticking in Drosophila, did not compromise rhythmicity in P. apterus, it only accelerated its pace. Furthermore, silencing timeless-m, the ancestral timeless type ubiquitously present across animals, resulted in a mild gradual loss of rhythmicity, supporting its possible participation in the linden bug clock, which is consistent with timeless-m role suggested by research on mammalian models. The dispensability of timeless-d in P. apterus allows drawing a scenario in which the clock has remained functional at each step of transition from an ancestral state to the TIM-d-independent PER þ CRY-m system operating in extant vertebrates, including humans.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Biology and Evolution

ISSN

0737-4038

e-ISSN

1537-1719

Volume of the periodical

39

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

msab346

UT code for WoS article

000771141500014

EID of the result in the Scopus database

2-s2.0-85123878132