Chiral secondary amino acids, their importance, and methods of analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00555383" target="_blank" >RIV/60077344:_____/22:00555383 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/content/pdf/10.1007/s00726-022-03136-6.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1007/s00726-022-03136-6.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00726-022-03136-6" target="_blank" >10.1007/s00726-022-03136-6</a>
Alternative languages
Result language
angličtina
Original language name
Chiral secondary amino acids, their importance, and methods of analysis
Original language description
Naturally occurring secondary amino acids, with proline as the main representative, contain an alpha-imino group in a cycle that is typically four-, five-, and six-membered. The unique ring structure exhibits exceptional properties—conformational rigidity, chemical stability, and specific roles in protein structure and folding. Many proline analogues have been used as valuable compounds for the study of metabolism of both prokaryotic and eukaryotic cells and for the synthesis of compounds with desired biological, pharmaceutical, or industrial properties. The d-forms of secondary amino acids play different roles in living organisms than the l-forms. They have different metabolic pathways, biological, physiological, and pharmacological effects, they can be indicators of changes and also serve as biomarkers of diseases. In the scientific literature, the number of articles examining d-amino acids in biological samples is increasing. The review summarises information on the occurrence and importance of d- and l-secondary amino acids—azetidic acid, proline, hydroxyprolines, pipecolic, nipecotic, hydroxypipecolic acids and related peptides containing these d-AAs, as well as the main analytical methods (mostly chromatographic) used for their enantiomeric determination in different matrices (biological samples, plants, food, water, and soil).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Amino Acids
ISSN
0939-4451
e-ISSN
1438-2199
Volume of the periodical
54
Issue of the periodical within the volume
5
Country of publishing house
AT - AUSTRIA
Number of pages
33
Pages from-to
687-719
UT code for WoS article
000759341900001
EID of the result in the Scopus database
2-s2.0-85125098858