Mitochondrial adaptations throughout the Trypanosoma brucei life cycle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00564728" target="_blank" >RIV/60077344:_____/22:00564728 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/22:43905080
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/jeu.12911" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jeu.12911</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jeu.12911" target="_blank" >10.1111/jeu.12911</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial adaptations throughout the Trypanosoma brucei life cycle
Original language description
The unicellular parasite Trypanosoma brucei has a digenetic life cycle that alternates between a mammalian host and an insect vector. During programmed development, this extracellular parasite encounters strikingly different environments that determine its energy metabolism. Functioning as a bioenergetic, biosynthetic, and signaling center, the single mitochondrion of T. brucei is drastically remodeled to support the dynamic cellular demands of the parasite. This manuscript will provide an up-to-date overview of how the distinct T. brucei developmental stages differ in their mitochondrial metabolic and bioenergetic pathways, with a focus on the electron transport chain, proline oxidation, TCA cycle, acetate production, and ATP generation. Although mitochondrial metabolic rewiring has always been simply viewed as a consequence of the differentiation process, the possibility that certain mitochondrial activities reinforce parasite differentiation will be explored.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Eukaryotic Microbiology
ISSN
1066-5234
e-ISSN
1550-7408
Volume of the periodical
69
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
e12911
UT code for WoS article
000789853500001
EID of the result in the Scopus database
2-s2.0-85129296070