Polyenic antibiotics and other antifungal compounds produced by hemolytic Streptomyces species
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00565131" target="_blank" >RIV/60077344:_____/22:00565131 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13440/22:43897266 RIV/00216208:11110/22:10456087
Result on the web
<a href="https://www.mdpi.com/1422-0067/23/23/15045" target="_blank" >https://www.mdpi.com/1422-0067/23/23/15045</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms232315045" target="_blank" >10.3390/ijms232315045</a>
Alternative languages
Result language
angličtina
Original language name
Polyenic antibiotics and other antifungal compounds produced by hemolytic Streptomyces species
Original language description
Streptomyces are of great interest in the pharmaceutical industry as they produce a plethora of secondary metabolites that act as antibacterial and antifungal agents. They may thrive on their own in the soil, or associate with other organisms, such as plants or invertebrates. Some soil-derived strains exhibit hemolytic properties when cultivated on blood agar, raising the question of whether hemolysis could be a virulence factor of the bacteria. In this work we examined hemolytic compound production in 23 β-hemolytic Streptomyces isolates, of these 12 were soil-derived, 10 were arthropodassociated, and 1 was plant-associated. An additional human-associated S. sp. TR1341 served as a control. Mass spectrometry analysis suggested synthesis of polyene molecules responsible for the hemolysis: candicidins, filipins, strevertene A, tetrafungin, and tetrin A, as well as four novel polyene compounds (denoted here as polyene A, B, C, and D) in individual liquid cultures or paired cocultures. The non-polyene antifungal compounds actiphenol and surugamide A were also identified. The findings indicate that the ability of Streptomyces to produce cytolytic compounds (here manifested by hemolysis on blood agar) is an intrinsic feature of the bacteria in the soil environment and could even serve as a virulence factor when colonizing available host organisms. Additionally, a literature review of polyenes and non-polyene hemolytic metabolites produced by Streptomyces is presented.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
1422-0067
Volume of the periodical
23
Issue of the periodical within the volume
23
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
15045
UT code for WoS article
000939115000001
EID of the result in the Scopus database
2-s2.0-85143702895