A human lung-associated Streptomyces sp. TR1341 produces various secondary metabolites responsible for virulence, cytotoxicity and modulation of immune response
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00525212" target="_blank" >RIV/60077344:_____/20:00525212 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13440/20:43895724 RIV/60076658:12310/20:43901395 RIV/00216208:11110/20:10411395
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fmicb.2019.03028/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmicb.2019.03028/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmicb.2019.03028" target="_blank" >10.3389/fmicb.2019.03028</a>
Alternative languages
Result language
angličtina
Original language name
A human lung-associated Streptomyces sp. TR1341 produces various secondary metabolites responsible for virulence, cytotoxicity and modulation of immune response
Original language description
Streptomycetes, typical soil dwellers, can be detected as common colonizers of human bodies, especially the skin, the respiratory tract, the guts and the genital tract using molecular techniques. However, their clinical manifestations and isolations are rare. Recently they were discussed as possible coaches of the human immune system in connection with certain immune disorders and cancer. This work aimed for the characterization and evaluation of genetic adaptations of a human-associated strain Streptomyces sp. TR1341. The strain was isolated from sputum of a senior male patient with a history of lung and kidney TB, recurrent respiratory infections and COPD. It manifested remarkably broad biological activities (antibacterial, antifungal, beta-hemolytic, etc.). We found that, by producing specific secondary metabolites, it is able to modulate host immune responses and the niche itself, which increase its chances for long-term survival in the human tissue. The work shows possible adaptations or predispositions of formerly soil microorganism to survive in human tissue successfully. The strain produces two structural groups of cytotoxic compounds: 28-carbon cytolytic polyenes of the filipin type and actinomycin X2. Additionally, we summarize and present data about streptomycete-related human infections known so far.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10609 - Biochemical research methods
Result continuities
Project
<a href="/en/project/NV17-30091A" target="_blank" >NV17-30091A: Unique biosynthetic enzymes as the key to novel bioactive compounds</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Microbiology
ISSN
1664-302X
e-ISSN
—
Volume of the periodical
10
Issue of the periodical within the volume
January
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
3028
UT code for WoS article
000510722500001
EID of the result in the Scopus database
2-s2.0-85078843060