Repeat-based holocentromeres influence genome architecture and karyotype evolution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00568618" target="_blank" >RIV/60077344:_____/22:00568618 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/22:00568618 RIV/60076658:12310/22:43904991
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0092867422007978?via%3Dihub#kwrds0010" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0092867422007978?via%3Dihub#kwrds0010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cell.2022.06.045" target="_blank" >10.1016/j.cell.2022.06.045</a>

Result language
angličtina
Original language name
Repeat-based holocentromeres influence genome architecture and karyotype evolution
Original language description
The centromere represents a single region in most eukaryotic chromosomes. However, several plant and animal lineages assemble holocentromeres along the entire chromosome length. Here, we compare genome organization and evolution as a function of centromere type by assembling chromosome-scale hol-ocentric genomes with repeat-based holocentromeres from three beak-sedge (Rhynchospora pubera, R. breviuscula, and R. tenuis) and their closest monocentric relative, Juncus effusus. We demonstrate that transition to holocentricity affected 3D genome architecture by redefining genomic compartments, while distributing centromere function to thousands of repeat-based centromere units genome-wide. We uncover a complex genome organization in R. pubera that hides its unexpected octoploidy and describe a marked reduction in chromosome number for R. tenuis, which has only two chromosomes. We show that chromo-some fusions, facilitated by repeat-based holocentromeres, promoted karyotype evolution and diploidiza-tion. Our study thus sheds light on several important aspects of genome architecture and evolution influenced by centromere organization.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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