Effect of population size and selection on Toll-like receptor diversity in populations of Galapagos mockingbirds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00567728" target="_blank" >RIV/60077344:_____/23:00567728 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/23:10462156 RIV/60076658:12310/23:43906407

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/10.1111/jeb.14121" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/jeb.14121</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jeb.14121" target="_blank" >10.1111/jeb.14121</a>

Result language

angličtina

Original language name

Effect of population size and selection on Toll-like receptor diversity in populations of Galapagos mockingbirds

Original language description

The interactions of evolutionary forces are difficult to analyse in free-living populations. However, when properly understood, they provide valuable insights into evolutionary biology and conservation genetics. This is particularly important for the interplay of genetic drift and natural selection in immune genes that confer resistance to disease. The Galapagos Islands are inhabited by four closely related species of mockingbirds (Mimus spp.). We used 12 different-sized populations of Galapagos mockingbirds and one population of their continental relative northern mockingbird (Mimus polyglottos) to study the effects of genetic drift on the molecular evolution of immune genes, the Toll-like receptors (TLRs: TLR1B, TLR4 and TLR15). We found that neutral genetic diversity was positively correlated with island size, indicating an important effect of genetic drift. However, for TLR1B and TLR4, there was little correlation between functional (e.g., protein) diversity and island size, and protein structural properties were largely conserved, indicating only a limited effect of genetic drift on molecular phenotype. By contrast, TLR15 was less conserved and even its putative functional polymorphism correlated with island size. The patterns observed for the three genes suggest that genetic drift does not necessarily dominate selection even in relatively small populations, but that the final outcome depends on the degree of selection constraint that is specific for each TLR locus.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

40301 - Veterinary science

Project

<a href="/en/project/GJ19-20152Y" target="_blank" >GJ19-20152Y: Effects of microbiota composition on inflammatory immunity and clinical symptom occurrence in socioeconomically-relevant parrots</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Evolutionary Biology

ISSN

1010-061X

e-ISSN

1420-9101

Volume of the periodical

36

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

109-120

UT code for WoS article

000888871100001

EID of the result in the Scopus database

2-s2.0-85142252635