Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00468811" target="_blank" >RIV/60077344:_____/16:00468811 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/16:43890846 RIV/46747885:24620/16:00000829
Result on the web
<a href="http://dx.doi.org/10.1111/mec.13807" target="_blank" >http://dx.doi.org/10.1111/mec.13807</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/mec.13807" target="_blank" >10.1111/mec.13807</a>
Alternative languages
Result language
angličtina
Original language name
Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds
Original language description
The extracellular subunit of the major histocompatibility complex MHCII plays an important role in the recognition of pathogens and the initiation of the adaptive immune response of vertebrates. It is widely accepted that pathogen-mediated selection in combination with neutral micro-evolutionary forces (e.g. genetic drift) shape the diversity of MHCII, but it has proved difficult to determine the relative effects of these forces. We evaluated the effect of genetic drift and balancing selection on MHCII diversity in 12 small populations of Galapagos mockingbirds belonging to four different species, and one larger population of the Northern mockingbird from the continental USA. After genotyping MHCII loci by high-throughput sequencing, we applied a correlational approach to explore the relationships between MHCII diversity and population size by proxy of island size. As expected when drift predominates, we found a positive effect of population size on the number of MHCII alleles present in a population. However, the number of MHCII alleles per individual and number of supertypes were not correlated with population size. This discrepancy points to an interesting feature of MHCII diversity dynamics: some levels of diversity might be shaped by genetic drift while others are independent and possibly maintained by balancing selection.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EG - Zoology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Ecology
ISSN
0962-1083
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
16
Pages from-to
4757-4772
UT code for WoS article
000384810000006
EID of the result in the Scopus database
2-s2.0-84988959590