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Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00468811" target="_blank" >RIV/60077344:_____/16:00468811 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/16:43890846 RIV/46747885:24620/16:00000829

  • Result on the web

    <a href="http://dx.doi.org/10.1111/mec.13807" target="_blank" >http://dx.doi.org/10.1111/mec.13807</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/mec.13807" target="_blank" >10.1111/mec.13807</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Balancing selection and genetic drift create unusual patterns of MHCII variation in Galapagos mockingbirds

  • Original language description

    The extracellular subunit of the major histocompatibility complex MHCII plays an important role in the recognition of pathogens and the initiation of the adaptive immune response of vertebrates. It is widely accepted that pathogen-mediated selection in combination with neutral micro-evolutionary forces (e.g. genetic drift) shape the diversity of MHCII, but it has proved difficult to determine the relative effects of these forces. We evaluated the effect of genetic drift and balancing selection on MHCII diversity in 12 small populations of Galapagos mockingbirds belonging to four different species, and one larger population of the Northern mockingbird from the continental USA. After genotyping MHCII loci by high-throughput sequencing, we applied a correlational approach to explore the relationships between MHCII diversity and population size by proxy of island size. As expected when drift predominates, we found a positive effect of population size on the number of MHCII alleles present in a population. However, the number of MHCII alleles per individual and number of supertypes were not correlated with population size. This discrepancy points to an interesting feature of MHCII diversity dynamics: some levels of diversity might be shaped by genetic drift while others are independent and possibly maintained by balancing selection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EG - Zoology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Ecology

  • ISSN

    0962-1083

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    19

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    16

  • Pages from-to

    4757-4772

  • UT code for WoS article

    000384810000006

  • EID of the result in the Scopus database

    2-s2.0-84988959590