Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00567732" target="_blank" >RIV/60077344:_____/23:00567732 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/23:43907223 RIV/00216208:11310/23:10450787 RIV/00216208:11120/23:43924309
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1567724922001039?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1567724922001039?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mito.2022.11.006" target="_blank" >10.1016/j.mito.2022.11.006</a>
Alternative languages
Result language
angličtina
Original language name
Selective and reversible disruption of mitochondrial inner membrane protein complexes by lipophilic cations
Original language description
Triphenylphosphonium (TPP) derivatives are commonly used to target chemical into mitochondria. We show that alkyl-TPP cause reversible, dose-and hydrophobicity-dependent alterations of mitochondrial morphology and function and a selective decrease of mitochondrial inner membrane proteins including subunits of the res-piratory chain complexes, as well as components of the mitochondrial calcium uniporter complex. The treatment with alkyl-TPP resulted in the cleavage of the pro-fusion and cristae organisation regulator Optic atrophy-1. The structural and functional effects of alkyl-TPP were found to be reversible and not merely due to loss of membrane potential. A similar effect was observed with the mitochondria-targeted antioxidant MitoQ.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mitochondrion
ISSN
1567-7249
e-ISSN
1872-8278
Volume of the periodical
68
Issue of the periodical within the volume
JAN
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
60-71
UT code for WoS article
000903717400001
EID of the result in the Scopus database
2-s2.0-85142480385