Natural Clerodendrum-derived tick repellent: learning from Nepali culture

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00574495" target="_blank" >RIV/60077344:_____/23:00574495 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s10493-023-00804-4" target="_blank" >https://link.springer.com/article/10.1007/s10493-023-00804-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10493-023-00804-4" target="_blank" >10.1007/s10493-023-00804-4</a>

Result language

angličtina

Original language name

Natural Clerodendrum-derived tick repellent: learning from Nepali culture

Original language description

Ticks attaching to ear canals of humans and animals are the cause of otoacariasis, common in rural areas of Nepal. The plant Clerodendrum viscosum is used in multiple indigenous systems of medicine by ethnic communities in the Indo-Nepali-Malaysian region. Visiting the Chitwan National Park, we learned that in indigenous medicine, flower extract of C. viscosum is utilized to treat digestive disorders and extracts from leaves as tick repellent to prevent ticks from invading or to remove them from the ear canal. The objective of our study was to provide support to indigenous medicine by characterizing the in vivo effect of leave extracts on ticks under laboratory conditions and its phytochemical composition. We collected plant parts of C. viscosum (leaves and flowers) and mango (Mangifera indica) leaves at the Chitwan National Park, previously associated with repellent activity to characterize their effect on Ixodes ricinus ticks by in vivo bioassays. A Q-ToF high-resolution analysis (HPLC-ESI-QToF) was conducted to elucidate phenolic compounds with potential repellent activity. Clerodendrum viscosum and M. indica leaf extracts had the highest tick repellent efficacy (%E = 80-100%) with significant differences when compared to C. viscosum flowers extracts (%E = 20-60%) and phosphate-buffered saline. Phytochemicals with tick repellent function as caffeic acid, fumaric acid and p-coumaric acid glucoside were identified in C. viscosum leaf extracts by HPLC-ESI-QToF, but not in non-repellent flower extracts. These results support the Nepali indigenous medicine application of C. viscosum leaf extracts to repel ticks. Additional research is needed for the development of natural and green repellent formulations to reduce the risks associated with ticks resistant to acaricides.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Applied Acarology

ISSN

0168-8162

e-ISSN

1572-9702

Volume of the periodical

90

Issue of the periodical within the volume

1-2

Country of publishing house

DE - GERMANY

Number of pages

16

Pages from-to

83-98

UT code for WoS article

001003148300004

EID of the result in the Scopus database

2-s2.0-85161373135