Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00580591" target="_blank" >RIV/60077344:_____/23:00580591 - isvavai.cz</a>
Result on the web
<a href="https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14747" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14747</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/1873-3468.14747" target="_blank" >10.1002/1873-3468.14747</a>
Alternative languages
Result language
angličtina
Original language name
Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes
Original language description
One of the remarkable features of eukaryotes is the nucleus, delimited by the nuclear envelope (NE), a complex structure and home to the nuclear lamina and nuclear pore complex (NPC). For decades, these structures were believed to be mainly architectural elements and, in the case of the NPC, simply facilitating nucleocytoplasmic trafficking. More recently, the critical roles of the lamina, NPC and other NE constituents in genome organisation, maintaining chromosomal domains and regulating gene expression have been recognised. Importantly, mutations in genes encoding lamina and NPC components lead to pathogenesis in humans, while pathogenic protozoa disrupt the progression of normal development and expression of pathogenesis-related genes. Here, we review features of the lamina and NPC across eukaryotes and discuss how these elements are structured in trypanosomes, protozoa of high medical and veterinary importance, highlighting lineage-specific and conserved aspects of nuclear organisation.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
0014-5793
e-ISSN
1873-3468
Volume of the periodical
597
Issue of the periodical within the volume
20
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
2501-2518
UT code for WoS article
001085520900001
EID of the result in the Scopus database
2-s2.0-85174145967