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Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00580591" target="_blank" >RIV/60077344:_____/23:00580591 - isvavai.cz</a>

  • Result on the web

    <a href="https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14747" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14747</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/1873-3468.14747" target="_blank" >10.1002/1873-3468.14747</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Evolutionary, structural and functional insights in nuclear organisation and nucleocytoplasmic transport in trypanosomes

  • Original language description

    One of the remarkable features of eukaryotes is the nucleus, delimited by the nuclear envelope (NE), a complex structure and home to the nuclear lamina and nuclear pore complex (NPC). For decades, these structures were believed to be mainly architectural elements and, in the case of the NPC, simply facilitating nucleocytoplasmic trafficking. More recently, the critical roles of the lamina, NPC and other NE constituents in genome organisation, maintaining chromosomal domains and regulating gene expression have been recognised. Importantly, mutations in genes encoding lamina and NPC components lead to pathogenesis in humans, while pathogenic protozoa disrupt the progression of normal development and expression of pathogenesis-related genes. Here, we review features of the lamina and NPC across eukaryotes and discuss how these elements are structured in trypanosomes, protozoa of high medical and veterinary importance, highlighting lineage-specific and conserved aspects of nuclear organisation.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    FEBS Letters

  • ISSN

    0014-5793

  • e-ISSN

    1873-3468

  • Volume of the periodical

    597

  • Issue of the periodical within the volume

    20

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    18

  • Pages from-to

    2501-2518

  • UT code for WoS article

    001085520900001

  • EID of the result in the Scopus database

    2-s2.0-85174145967