Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00582958" target="_blank" >RIV/60077344:_____/23:00582958 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00132153 RIV/65269705:_____/23:00078438 RIV/00027162:_____/23:N0000223
Result on the web
<a href="https://link.springer.com/article/10.1007/s13365-023-01182-8" target="_blank" >https://link.springer.com/article/10.1007/s13365-023-01182-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13365-023-01182-8" target="_blank" >10.1007/s13365-023-01182-8</a>
Alternative languages
Result language
angličtina
Original language name
Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis
Original language description
Tick-borne encephalitis (TBE) is a neuroviral disease that ranges in severity from a mild febrile illness to a severe and life-threatening meningoencephalitis or encephalomyelitis. There is increasing evidence that susceptibility to tick-borne encephalitis virus (TBEV)-induced disease and its severity are largely influenced by host genetic factors, in addition to other virus- and host-related factors. In this study, we investigated the contribution of selected single nucleotide polymorphisms (SNPs) in innate immunity genes to predisposition to TBE in humans. More specifically, we investigated a possible association between SNPs rs304478 and rs303212 in the gene Interferon Induced Protein With Tetratricopeptide Repeats 1 (IFIT1), rs7070001 and rs4934470 in the gene Interferon Induced Protein With Tetratricopeptide Repeats 2 (IFIT2), and RIG-I (Retinoic acid-inducible gene I) encoding gene DDX58 rs311795343, rs10813831, rs17217280 and rs3739674 SNPs with predisposition to TBE in population of the Czech Republic, where TBEV is highly endemic. Genotypic and allelic frequencies for these SNPs were analyzed in 247 nonimmunized TBE patients and compared with 204 control subjects. The analysis showed an association of IFIT1 rs304478 SNP and DDX58 rs3739674 and rs17217280 SNPs with predisposition to TBE in the Czech population indicating novel risk factors for clinical TBE but not for disease severity. These results also highlight the role of innate immunity genes in TBE pathogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurovirology
ISSN
1355-0284
e-ISSN
1538-2443
Volume of the periodical
29
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
699-705
UT code for WoS article
001089138900002
EID of the result in the Scopus database
2-s2.0-85174951547