Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00582961" target="_blank" >RIV/60077344:_____/23:00582961 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00132674 RIV/62156489:43210/23:43924459 RIV/00027162:_____/23:N0000221
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202303585" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202303585</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/slct.202303585" target="_blank" >10.1002/slct.202303585</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis and Antiviral Activity of 2′-Modified L-Nucleoside Analogues
Original language description
Nucleoside analogues have been the foundation of antiviral therapy over the past few decades. D-nucleosides with natural stereochemistry occupies the lion share of the marketed antiviral agents. However, much less effort have been put towards the development of L-nucleosides as antiviral agents. Herein, our effort towards the synthesis of 2 'substituted L-nucleoside analogues is reported as an emerging class of antiviral agents. Biological activity of the synthesized L-nucleosided was evaluated against two viruses of importance, tick-borne encephalitis virus (TBEV) and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in adenocarcinomic human alveolar basal epithelial cells (A459) and Vero cells. Ring opening of L-2, 2 '-Anhydrouridine (2) with various nucleophiles to make several 2'-substituted L-nucleosides is the key synthetic outcome. This development has paved the way in the synthesis of many new analogues of 2'-substituted L-nucleosides for numerous applications.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemistrySelect
ISSN
2365-6549
e-ISSN
2365-6549
Volume of the periodical
8
Issue of the periodical within the volume
48
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
e202303585
UT code for WoS article
001128722500001
EID of the result in the Scopus database
2-s2.0-85180209542