Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00583119" target="_blank" >RIV/60077344:_____/23:00583119 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/eci.13992" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/eci.13992</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei
Original language description
Background: In the last decade, the importance of mitochondrially derived reactive oxygen species (OS) as signals in intracellular communication has been sealed. These though-to-be harmful molecules influence cellular faith decisions and can drive cells towards proliferation, apoptosis or differentiation. The OS are mainly generated as by-products during the process of oxidative phosphorylation (OXPHOS), which is completed by FoF1-ATP synthase with the formation of ATP. In trypanosomes, unicellular parasites undergoing programmed life cycle development, the cellular differentiation is linked to increased mitochondrial metabolic activity and OS production.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů