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Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00583119" target="_blank" >RIV/60077344:_____/23:00583119 - isvavai.cz</a>

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1111/eci.13992" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/eci.13992</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dysregulation of mitochondrial bioenergetics leads to elevated ROS levels and promotes programmed developmental progression of Trypanosoma brucei

  • Original language description

    Background: In the last decade, the importance of mitochondrially derived reactive oxygen species (OS) as signals in intracellular communication has been sealed. These though-to-be harmful molecules influence cellular faith decisions and can drive cells towards proliferation, apoptosis or differentiation. The OS are mainly generated as by-products during the process of oxidative phosphorylation (OXPHOS), which is completed by FoF1-ATP synthase with the formation of ATP. In trypanosomes, unicellular parasites undergoing programmed life cycle development, the cellular differentiation is linked to increased mitochondrial metabolic activity and OS production.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů