Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00587342" target="_blank" >RIV/60077344:_____/24:00587342 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/24:00138780 RIV/62157124:16170/24:43881768 RIV/00027162:_____/24:N0000064
Result on the web
<a href="https://doi.org/10.1016/j.celrep.2024.114298" target="_blank" >https://doi.org/10.1016/j.celrep.2024.114298</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2024.114298" target="_blank" >10.1016/j.celrep.2024.114298</a>
Alternative languages
Result language
angličtina
Original language name
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses
Original language description
Flaviviruses such as dengue virus (DENV), Zika virus (ZIKV), and yellow fever virus (YFV) are spread by mosquitoes and cause human disease and mortality in tropical areas. In contrast, Powassan virus (POWV), which causes severe neurologic illness, is a flavivirus transmitted by ticks in temperate regions of the Northern hemisphere. We find serologic neutralizing activity against POWV in individuals living in Mexico and Brazil. Monoclonal antibodies P002 and P003, which were derived from a resident of Mexico (where POWV is not reported), neutralize POWV lineage I by recognizing an epitope on the virus envelope domain III (EDIII) that is shared with a broad range of tick- and mosquitoborne flaviviruses. Our findings raise the possibility that POWV, or a flavivirus closely related to it, infects humans in the tropics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/GF21-05445L" target="_blank" >GF21-05445L: Human antibodies to tick-borne flaviviruses</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2211-1247
e-ISSN
2211-1247
Volume of the periodical
43
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
114298
UT code for WoS article
001250327100001
EID of the result in the Scopus database
2-s2.0-85194413722