Co-infection dynamics of B. afzelii and TBEV in C3H mice: insights and implications for future research
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00597515" target="_blank" >RIV/60077344:_____/24:00597515 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/24:43908810
Result on the web
<a href="https://doi.org/10.1128/iai.00249-24" target="_blank" >https://doi.org/10.1128/iai.00249-24</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/iai.00249-24" target="_blank" >10.1128/iai.00249-24</a>
Alternative languages
Result language
angličtina
Original language name
Co-infection dynamics of B. afzelii and TBEV in C3H mice: insights and implications for future research
Original language description
Ticks are important vectors of disease, particularly in the context of One Health, where tick-borne diseases (TBDs) are increasingly prevalent worldwide. TBDs often involve co-infections, where multiple pathogens co-exist in a single host. Patients with chronic Lyme disease often have co-infections with other bacteria or parasites. This study aimed to create a co-infection model with Borrelia afzelii and tick-borne encephalitis virus (TBEV) in C3H mice and to evaluate symptoms, mortality, and pathogen level compared to single infections. Successful co-infection of C3H mice with B. afzelii and TBEV was achieved. Outcomes varied, depending on the timing of infection. When TBEV infection followed B. afzelii infection by 9 days, TBEV symptoms worsened and virus levels increased. Conversely, mice infected 21 days apart with TBEV showed milder symptoms and lower mortality. Simultaneous infection resulted in mild symptoms and no deaths. However, our model did not effectively infect ticks with TBEV, possibly due to suboptimal dosing, highlighting the challenges of replicating natural conditions. Understanding the consequences of co-infection is crucial, given the increasing prevalence of TBD. Co-infected individuals may experience exacerbated symptoms, highlighting the need for a comprehensive understanding through refined animal models. This study advances knowledge of TBD and highlights the importance of exploring co-infection dynamics in host-pathogen interactions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Infection and Immunity
ISSN
0019-9567
e-ISSN
1098-5522
Volume of the periodical
92
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
e0024924
UT code for WoS article
001266157800001
EID of the result in the Scopus database
2-s2.0-85202756383