Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00599352" target="_blank" >RIV/60077344:_____/24:00599352 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/24:00599352 RIV/00216208:11110/24:10485838
Result on the web
<a href="https://doi.org/10.1038/s42003-024-06819-w" target="_blank" >https://doi.org/10.1038/s42003-024-06819-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-024-06819-w" target="_blank" >10.1038/s42003-024-06819-w</a>
Alternative languages
Result language
angličtina
Original language name
Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome
Original language description
Metabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with symptoms of metabolic syndrome and may, therefore, be relevant players in the genetics of metabolic syndrome. We investigate the effect of mitochondrial sequence variation on the metabolic phenotype in conplastic rat strains with identical nuclear but unique mitochondrial genomes, challenged by high-fat diet. We find that the variation in mitochondrial rRNA sequence represents risk factor in the insulin resistance development, which is associated with diacylglycerols accumulation, induced by tissue-specific reduction of the oxidative capacity. These metabolic perturbations stem from the 12S rRNA sequence variation affecting mitochondrial ribosome assembly and translation. Our work demonstrates that physiological variation in mitochondrial rRNA might represent a relevant underlying factor in the progression of metabolic syndrome.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Communications Biology
ISSN
2399-3642
e-ISSN
2399-3642
Volume of the periodical
7
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
1116
UT code for WoS article
001311131100003
EID of the result in the Scopus database
2-s2.0-85203494449