Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00600338" target="_blank" >RIV/60077344:_____/24:00600338 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/24:00600338

Result on the web

<a href="https://doi.org/10.1016/j.bbabio.2024.149465" target="_blank" >https://doi.org/10.1016/j.bbabio.2024.149465</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome

Original language description

Obesity and its associated comorbidities, particularly metabolic syndrome, are a growing problem in developed societies. Due to its polygenic nature, the genetic component of metabolic syndrome is only slowly being elucidated. Common mitochondrial DNA (mtDNA) sequence variants have been associated with late-onset human diseases, including cardiovascular disease or type 2 diabetes mellitus, and may therefore be relevant players in the genetics of metabolic syndrome. Our work has demonstrated that physiological sequence variation in mitochondrial rRNA may be a relevant underlying factor in the progression of metabolic syndrome.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů