KU70 and CAF-1 in Arabidopsis: Divergent roles in rDNA stability and telomere homeostasis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F24%3A00601712" target="_blank" >RIV/60077344:_____/24:00601712 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/24:00601712 RIV/00216224:14740/24:00137143 RIV/60076658:12310/24:43908875
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/tpj.16718" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/tpj.16718</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tpj.16718" target="_blank" >10.1111/tpj.16718</a>

Result language
angličtina
Original language name
KU70 and CAF-1 in Arabidopsis: Divergent roles in rDNA stability and telomere homeostasis
Original language description
Deficiency in chromatin assembly factor-1 (CAF-1) in plants through dysfunction of its components, FASCIATA1 and 2 (FAS1, FAS2), leads to the specific and progressive loss of rDNA and telomere repeats in plants. This loss is attributed to defective repair mechanisms for the increased DNA breaks encountered during replication, a consequence of impaired replication-dependent chromatin assembly. In this study, we explore the role of KU70 in these processes. Our findings reveal that, although the rDNA copy number is reduced in ku70 mutants when compared with wild-type plants, it is not markedly affected by diverse KU70 status in fas1 mutants. This is consistent with our previous characterisation of rDNA loss in fas mutants as a consequence part of the single-strand annealing pathway of homology-dependent repair. In stark contrast to rDNA, KU70 dysfunction fully suppresses the loss of telomeres in fas1 plants and converts telomeres to their elongated and heterogeneous state typical for ku70 plants. We conclude that the alternative telomere lengthening pathway, known to be activated in the absence of KU70, overrides progressive telomere loss due to CAF-1 dysfunction.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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