SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00618897" target="_blank" >RIV/60077344:_____/25:00618897 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12220/25:43909779 RIV/60076658:12310/25:43909779

Result on the web

<a href="https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5L2VsaWZlLTEwNTAzOS12MS5wZGY_Y2Fub25pY2FsVXJpPWh0dHBzOi8vZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5/elife-105039-v1.pdf?_hash=X63s%2F0uvn60DRBU1NWVUkrKbc7qba2FGTCWiX4bLeAI%3D" target="_blank" >https://elifesciences.org/download/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5L2VsaWZlLTEwNTAzOS12MS5wZGY_Y2Fub25pY2FsVXJpPWh0dHBzOi8vZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvMTA1MDM5/elife-105039-v1.pdf?_hash=X63s%2F0uvn60DRBU1NWVUkrKbc7qba2FGTCWiX4bLeAI%3D</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7554/eLife.105039.3" target="_blank" >10.7554/eLife.105039.3</a>

Result language

angličtina

Original language name

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

Original language description

During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response. S-adenosylmethionine (SAM) is a methyl group donor for most methylations in the cell and is synthesized from methionine and ATP. After methylation, SAM is converted to S-adenosylhomocysteine, which is further metabolized to adenosine and homocysteine. Here, we show that the SAM transmethylation pathway is up-regulated during immune cell activation and that the adenosine produced by this pathway in immune cells acts as a systemic signal to delay Drosophila larval development and ensure sufficient nutrient supply to the immune system. We further show that the up-regulation of the SAM transmethylation pathway and the efficiency of the immune response also depend on the recycling of adenosine back to ATP by adenosine kinase and adenylate kinase. We therefore hypothesize that adenosine may act as a sensitive sensor of the balance between cell activity, represented by the sum of methylation events in the cell, and nutrient supply. If the supply of nutrients is insufficient for a given activity, adenosine may not be effectively recycled back into ATP and may be pushed out of the cell to serve as a signal to demand more nutrients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

eLife

ISSN

2050-084X

e-ISSN

2050-084X

Volume of the periodical

13

Issue of the periodical within the volume

APR 07

Country of publishing house

GB - UNITED KINGDOM

Number of pages

39

Pages from-to

RP105039

UT code for WoS article

001462287600001

EID of the result in the Scopus database

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