Coevolution of Drosophila-type timeless with partner clock proteins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00619286" target="_blank" >RIV/60077344:_____/25:00619286 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/25:43910100
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2589004225005991/pdfft?md5=d4f9f780516faabc1949428e3b7ea81c&pid=1-s2.0-S2589004225005991-main.pdf" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2589004225005991/pdfft?md5=d4f9f780516faabc1949428e3b7ea81c&pid=1-s2.0-S2589004225005991-main.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2025.112338" target="_blank" >10.1016/j.isci.2025.112338</a>

Result language
angličtina
Original language name
Coevolution of Drosophila-type timeless with partner clock proteins
Original language description
Drosophila-type timeless (dTIM) is a key clock protein in fruit flies, regulating rhythmicity and light-mediated entrainment. However, functional experiments indicate that its contribution to the clock differs in various insects. Therefore, we conducted a comprehensive phylogenetic analysis of dTIM across animals and dated its origin, gene duplications, and losses. We identified variable and conserved protein domains and pinpointed animal lineages that underwent the biggest changes in dTIM. While dTIM modifications are only mildly affected by changes in the PER protein, even the complete loss of PER in echinoderms had no impact on dTIM. However, changes in dTIM always co-occur with the loss of CRYPTOCHROMES or JETLAG. This is exemplified by the remarkably accelerated evolution of dTIM in phylloxera and aphids. Finally, alternative d-tim splicing, characteristic of Drosophila melanogaster temperature-dependent function, is conserved to some extent in Diptera, albeit with unique alterations. Altogether, this study pinpoints major changes that shaped dTIM evolution.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10605 - Developmental biology

Project
<a href="/en/project/GA22-10088S" target="_blank" >GA22-10088S: Functional Analysis of Drosophila Timeless Protein</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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