Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F25%3A00645063" target="_blank" >RIV/60077344:_____/25:00645063 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/25:00645063 RIV/00216224:14310/25:00144627 RIV/00027162:_____/25:N0000140

Result on the web

<a href="https://doi.org/10.1099/jgv.0.002161" target="_blank" >https://doi.org/10.1099/jgv.0.002161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1099/jgv.0.002161" target="_blank" >10.1099/jgv.0.002161</a>

Result language

angličtina

Original language name

Sex-dependent impairment of antibody responses to tick-borne encephalitis virus vaccination and infection in obese mice

Original language description

Obesity is a growing global health concern with profound effects on immune function and vaccine efficacy. This study investigated the impact of obesity on immune responses to tick-borne encephalitis virus (TBEV) vaccination and infection using a mouse model. Mice on a high-fat diet (HFD) exhibited increased body weight, fat mass and a pre-diabetic state compared to standard chow diet (SCD) controls. After vaccination with the TBEV vaccine (Encepur), HFD mice showed significantly lower TBEV-specific IgG titres and neutralizing antibody levels compared to SCD mice. Splenocyte counts per organ mass were significantly higher in vaccinated SCD mice compared to their HFD counterparts, correlating with the elevated IgG titres observed in the SCD group. These results underscore the critical role of diet in shaping the immune response and vaccine efficacy. Following TBEV infection, HFD mice did not display increased disease severity or elevated viral titres in the serum, spleen or brain relative to SCD controls, indicating that obesity did not exacerbate viral replication or dissemination. However, a sex-dependent effect of obesity on the humoral immune response was observed. Male HFD mice produced antibody titres comparable to their SCD counterparts, suggesting minimal impact of obesity on their immune response. In contrast, female HFD mice exhibited significant impairments in TBEV-specific IgG and neutralizing antibody production compared to female SCD mice, as well as both male HFD and male SCD groups. These findings highlight a complex interplay between obesity, sex and immune function, with obesity disproportionately impairing the immune response after TBEV vaccination and infection.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10607 - Virology

Project

<a href="/en/project/GA23-07160S" target="_blank" >GA23-07160S: Molecular pathogenesis of alimentary infection by tick-borne encephalitis virus.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of General Virology

ISSN

0022-1317

e-ISSN

1465-2099

Volume of the periodical

106

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

002161

UT code for WoS article

001622972000002

EID of the result in the Scopus database

2-s2.0-105017937395