Isect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077395%3A_____%2F01%3A60010013" target="_blank" >RIV/60077395:_____/01:60010013 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Isect silk contains both a Kunitz-type and a unique Kazal-type proteinase inhibitor.
Original language description
We demonstrated that two of the small peptides present in the silk of the waxmoth, Galleria mellonella , inhibit proteolytic enzymes, and are thus called silk proteinase inhibitors 1 and 2 (SPI 1, SPI 2). The full length cDNA of pre-SPI 1 contains 443 ntand encodes a peptide of 76 amino acid residues, of which 20 make up a signal sequence. The mature SPI 1 (6056.7 Da, 56 residues) is a typical thermostable Kunitz-type proteinase inhibitor. The cDNA of pre-SPI 2 consists of 260 nt and yields a putativesecretory peptide of 58 amino acid residues. The functional SPI 2 (3993 Da, 36 residues), is a single-domain Kazal-type proteinase inhibitor with unique structural features. Since SPI 1 and SPI 2 effectively inhibit bacterial and fungal proteinases theymay protect silk against microbial degradation.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)