The analyssis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: The S100A9 and S100A8 positive cells underlie and invade tumor mass

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F00%3A00000449" target="_blank" >RIV/60162694:G16__/00:00000449 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G38__/00:00000449

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The analyssis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: The S100A9 and S100A8 positive cells underlie and invade tumor mass

Original language description

The expression of calcium-binding protein S100A9 was investigated in 23 matched sets of colorectal carcinoma and normal colon mucosa using two-dimensional gel electrophoresis. We found that, from a group of 23 patients, the level of S100A9 protein, incomparison with matched normal colon mucosa, was significantly increased in malignant tissues of 16 patients (70%). Furthermore, an additional protein, identified by matrix-assisted laser desorption/ionization - mass spectrometry (MALDI-MS) as S100A8 , exhibited an increased expression in the same specimens of malignant tissues as the S100A9 protein. The immunohistological analysis revealed the accumulation of S100A9 positive cells, macrophages and polymorphonuclear leukocytes along the invasive margin ofcolorectal carcinoma. The S100A8 protein was found to be produced in the same location. The possible participation of both proteins and, especially, its heterodimeric complex calprotectin in colorectal carcinoma regression could be taken

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/LN00A033" target="_blank" >LN00A033: The proteome center for the study of intracellular parasitism of microbes</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2000

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

From genome to proteome

ISBN

3-527-30154-2

Number of pages of the result

8

Pages from-to

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Number of pages of the book

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Publisher name

WILEY-VCH Verlag GmbH

Place of publication

Weinheim

UT code for WoS chapter

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