Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG16__%2F03%3A00000903" target="_blank" >RIV/60162694:G16__/03:00000903 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G38__/03:00000903
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Reactivation of organophosphate inhibited acetylcholinesterase activity by a,w-bis-(4-hydroxyiminomethylpyridinium) alcanes in vitro
Original language description
In this article, we have followed up the relationship between the ability to reactivate acetylcholinesterase inhibited by organophosphorus compounds and the length of linking chainbetween two 4-hydroxyiminomethylpyridinium rings of acetylcholinesterase reactivators. aw-bis(4-hydroxyiminomethylpyridinium) alkanes have been used as the tested acetylcholinesterase reactivators. These oximes differ in the number of methylene groups on the connecting chain. A three or four membered linking chain seems to bethe ideal length for the satisfactory reactivation potency with the exception of reactivators of cyclosarin-inhibited acetylcholinesterase. In this case, the most efficacious acetylcholinesterase reactivator has one methylene group on the connecting chain
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)