Quaternary heteroarenium salts as the competitive inhibitors of the brain acetylcholinesterase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001075" target="_blank" >RIV/60162694:G38__/04:00001075 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Quaternary heteroarenium salts as the competitive inhibitors of the brain acetylcholinesterase

Original language description

The interaction of seventeen heteroarenium salts with the enzyme acetylcholinesterase was investigated using in vitro experiments. Rat brains were used as a source of the enzyme. All compounds involved in this study were found to be competitive acetylcholinesterase inhibitors. 10-methyl-acridinium iodide seems to be the most potent acetylcholinesterase inhibitor.

Czech name

Kvartérní heteroareniové soli jako kompetitivní inhibitory mozkové acetylcholinesterázy

Czech description

Kvartérní heteroareniové soli jako kompetitivní inhibitory mozkové acetylcholinesterázy

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Letters in Drug Design and Discovery

ISSN

1570-1808

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

2

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

4

Pages from-to

97-100

UT code for WoS article

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EID of the result in the Scopus database

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