Kinetics of In Vitro Inhibition of Acetylcholinesterase by Nineteen New Carbamates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39895922" target="_blank" >RIV/00216275:25310/11:39895922 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2174/157340811799860560" target="_blank" >http://dx.doi.org/10.2174/157340811799860560</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/157340811799860560" target="_blank" >10.2174/157340811799860560</a>
Alternative languages
Result language
angličtina
Original language name
Kinetics of In Vitro Inhibition of Acetylcholinesterase by Nineteen New Carbamates
Original language description
Two series A and B of 12 and 7 new carbamate derivates were tested in vitro as acetylcholinesterase inhibitors. The tests were performed in the batch stirred reactor at 25°C, pH 8, ionic strength 0.11 M and catalytic activity of the enzyme preparation 0.14 U mL-1 of the reaction mixture. The temporal dependences of actual concentrations of acetylcholine, choline and acetic acid were determined by two independent analytical methods, HPLC and pH-stat. For all used inhibitors, the model of competitive irreversible inhibition was valid. The inhibition rate constant k3 and qualified estimation of the absolute acetylcholinesterase concentration in the reaction mixture were calculated. The partition coefficients Kow between n-octanol and water of all used inhibitors were determined. The k3 and Kow values were correlated with the Hammett and Hansch substituent constants and with the calculated docking and binding energies of the reaction between the tested inhibitors and acetylcholinesterase.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Enzyme Inhibition
ISSN
1573-4080
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
236-243
UT code for WoS article
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EID of the result in the Scopus database
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