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1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001077" target="_blank" >RIV/60162694:G38__/04:00001077 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    1,3-bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents

  • Original language description

    The oxime K005 [1,3-bis(2-hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX were tested. Its reactivation potency was not better in comparison with the currentlyused AChE reactivator - pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10-4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10-1 M [for cyclosarin] and 10-3 M [for VX] but these concentrations are not available for the use in vivo.

  • Czech name

    1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami

  • Czech description

    1,3-bis(2-hydroxyiminomethylpyridinium) propan jako potenciální reaktivátor acetylcholinesterázy inhibované nervově paralytickými látkami

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Acta Medica (Hradec Králové)

  • ISSN

    1211-4286

  • e-ISSN

  • Volume of the periodical

    47

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    3

  • Pages from-to

    167-169

  • UT code for WoS article

  • EID of the result in the Scopus database