Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG38__%2F04%3A00001079" target="_blank" >RIV/60162694:G38__/04:00001079 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent
Original language description
A comparison of one mono- and seven bis-quaternary AChE reactivators of acetylcholinesterase inhibited by VX agent was performed. As a source of the acetylcholinesterase, a rat brain homogenate was taken. There were significant differences in reactivation potency of all tested oximes. The oxime TO 205 seems to be the most efficacious followed by TO 046, HI-6, HS-6, K027, obidoxime, MMC and 2-PAM. In addition, the results of this study showed, that the reactivation potency of the tested reactivators depends on many factors - such as the number of pyridinium rings, the number of oxime groups and their position, as well as the length and the shape of linkage bridge between two pyridinium rings.
Czech name
Oximy indukovaná reaktivaceacetylcholinesterázy z krysích mozků inhibované látkou VX
Czech description
Oximy indukovaná reaktivaceacetylcholinesterázy z krysích mozků inhibované látkou VX

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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