A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001309" target="_blank" >RIV/60162694:G44__/05:00001309 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods
Original language description
A potency of newly developed and currently used oximes to reactivate sarin-inhibited acetylcholinesterase was evaluated using in vitro methods. A rat brain homogenate was taken as a source of acetylcholinesterase. Significant differences in reactivationpotency among all tested oximes were observed. Although the ability of newly developed oximes to reactivate sarin-inhibited acetylcholinesterase does not reach the reactivating potency of the oxime HI-6, the oxime K033 seems to be more efficacious reactivator of sarin-inhibited acetylcholinesterase than other currently available oximes (pralidoxime, obidoxime) at concentrations (10-5 - 10-4 M) corresponding to recommended doses in vivo. The results of our study also confirm that the reactivation potencyof the tested reactivators depends on many factors - such as (1) the number of pyridinium rings, (2) the number of oxime groups and their position, and (3) the length and the shape of linkage bridge between both pyridinium rings.
Czech name
Srovnávání schopnosti nově vyvinutých oximů (K005, K027, K033, K048) a současně užívaných oximů (pralidoxim, obidoxim, HI-6) při reaktivaci sarinem-i nhibované acetylcholinesterázy krysího mozku metodou in vitro
Czech description
Srovnávání schopnosti nově vyvinutých oximů (K005, K027, K033, K048) a současně užívaných oximů (pralidoxim, obidoxim, HI-6) při reaktivaci sarinem-i nhibované acetylcholinesterázy krysího mozku metodou in vitro.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Toxicology and Environmental Health
ISSN
0098-4108
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
677-686
UT code for WoS article
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EID of the result in the Scopus database
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